USP36

Across TCGA pan-cancer cohorts, USP36 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated USP36 data layer compared with 6 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher USP36 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated USP36 expression acts as an unfavorable survival marker, although some lineages such as BRCA and READ show a favorable association.

KIRP, UCEC, and LIHC are the cancer types where USP36 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Quartile	III,IV	0.141	0.656	<.001	118	view →
UCEC	DFS	Median	All	0.780	0.891	<.001	52	view →
LIHC	DFS	Median	All	0.450	0.637	<.001	50	view →
KIRC	DFS	Tertile	IV	0.203	0.525	.002	45	view →
BLCA	DFS	Tertile	All	0.220	0.608	<.001	45	view →
BRCA	OS	Tertile	III,IV	0.949	0.834	.001	38	view →
READ	OS	Median	IV	0.913	0.507	.004	38	view →
ACC	DFS	Quartile	All	0.262	0.702	.002	32	view →
LGG	DFS	Quartile	All	0.767	0.898	.002	19	view →
LUAD	OS	Tertile	III,IV	0.610	0.295	.007	14	view →
PAAD	OS	Tertile	All	0.730	0.426	.001	12	view →
SCLC	DFS	Median	II,III,IV	0.984	0.427	.009	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

USP36–KIRP (DFS)

Open the KIRP breakdown →