USP36

Across TCGA pan-cancer cohorts, USP36 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of USP36’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where USP36 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types USP36 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

COAD, HNSC, and LIHC are the cancer types where USP36 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in USP36 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	+0.975	<.001	11	view →
HNSC	Male	III,IV	+0.841	<.001	11	view →
LIHC	Male	II,III,IV	+1.027	<.001	9	view →
THCA	All	All	−0.347	<.001	7	view →
CHOL	All	All	+2.008	<.001	5	view →
STAD	Male	II,III,IV	+1.025	<.001	4	view →
LUSC	Male	III,IV	+0.990	.007	4	view →
KIRC	All	All	+0.287	<.001	4	view →
KIRP	All	IV	+1.065	.002	3	view →
KICH	Female	All	−0.565	.008	3	view →
READ	All	All	+0.848	.004	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

USP36–COAD

Open the COAD breakdown →