USP36

Across TCGA patient cohorts, USP36 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USP36-associated genes across cancer lineages are p90 RSK, Caspase-7-cleavedD198, and AMPK_pT172. Each is linked with USP36 in more than 2 cancer types. Because this analysis shows association rather than direction, both USP36-to-partner and partner-to-USP36 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p90 RSK grouped by USP36-low versus USP36-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP36→partner) and Y-score (partner→USP36) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	p90 RSK →	+0.220	+3.000	.029	.035	3	3
UCEC	Caspase-7-cleavedD198 →	+0.540	+1.584	.001	.015	3	3
SKCM	AMPK_pT172 →	+0.423	+3.584	.007	.002	3	2
SKCM	c-Kit →	-0.726	-2.459	.020	.020	3	2
UCEC	14-3-3_beta →	-0.079	-1.821	.005	.007	3	2
UCEC	JNK_pT183_Y185 →	-0.163	-2.662	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

p90 RSK by USP36 expression — SKCM

Explore this box plot interactively →