USP36

Across TCGA cell cohorts, USP36 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,645 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible USP36-associated GO terms across cancer lineages are Regulation of transcription of nucleolar large rRNA by RNA polymerase I, Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I, and RNA catabolic process. Each is linked with USP36 in more than 16 cancer types. Because this analysis shows association rather than direction, both USP36-to-partner and partner-to-USP36 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of transcription of nucleolar large rRNA by RNA polymerase I grouped by USP36-low versus USP36-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (USP36→partner) and Y-score (partner→USP36) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.203	+0.888	<.001	<.001	3	17
BONE	Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.213	+1.067	<.001	<.001	3	16
LUNG_NSCLC_LUSC	RNA catabolic process →	+0.053	+0.659	<.001	<.001	3	14
BONE	Pre-mRNA catabolic process →	+0.240	+0.992	.001	.001	3	14
UPPER_AERODIGESTIVE_TRACT	Nuclear transport →	+0.074	+0.779	.003	.008	3	13
UPPER_AERODIGESTIVE_TRACT	Nucleocytoplasmic transport →	+0.074	+0.952	.003	.003	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,645 associations by consensus.

Regulation of transcription of nucleolar large rRNA by RNA polymerase I by USP36 expression — BONE

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