USP36

Across TCGA cell cohorts, USP36 mutation is significantly associated with the RNA expression of many other genes, with 277 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible USP36-associated genes across cancer lineages are MROH5, NUP58, and GPR3. Each is linked with USP36 in more than 1 cancer types. Because this analysis shows association rather than direction, both USP36-to-partner and partner-to-USP36 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MROH5 grouped by USP36-low versus USP36-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP36→partner) and Y-score (partner→USP36) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MROH5 →	+0.051	+4.371	<.001	.005	3	2
LARGE_INTESTINE	NUP58 →	+0.872	+3.169	<.001	.006	3	2
LARGE_INTESTINE	GPR3 →	+0.880	+3.502	<.001	.001	3	2
OESOPHAGUS	OR10AG1 →	+0.028	+3.857	.004	.002	3	1
OESOPHAGUS	IZUMO1R →	+0.118	+3.392	.001	.007	3	1
SOFT_TISSUE	SCGB1C1 →	+0.055	+4.977	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 277 associations by consensus.

MROH5 by USP36 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →