USP35

Across TCGA patient cohorts, USP35 mutation is significantly associated with the RNA expression of many other genes, with 2,255 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USP35-associated genes across cancer lineages are RPL12P5, UBE2WP1, and RPS29P32. Each is linked with USP35 in more than 2 cancer types. Because this analysis shows association rather than direction, both USP35-to-partner and partner-to-USP35 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL12P5 grouped by USP35-low versus USP35-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP35→partner) and Y-score (partner→USP35) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RPL12P5 →	+0.046	+4.289	<.001	.007	3	3
LUAD	UBE2WP1 →	+0.241	+5.376	<.001	.001	3	3
HNSC	RPS29P32 →	+0.658	+4.505	<.001	.009	3	3
BLCA	RBM7P1 →	+0.083	+3.873	.006	.004	3	2
BLCA	LINC01075 →	+0.090	+4.444	<.001	.006	3	2
BLCA	SAPCD2P2 →	+0.028	+4.497	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,255 associations by consensus.

RPL12P5 by USP35 expression — BLCA

Explore this box plot interactively →