USP35

Across TCGA patient cohorts, USP35 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USP35-associated genes across cancer lineages are Caspase-7-cleavedD198, Akt_pT308, and PTEN. Each is linked with USP35 in more than 2 cancer types. Because this analysis shows association rather than direction, both USP35-to-partner and partner-to-USP35 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by USP35-low versus USP35-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP35→partner) and Y-score (partner→USP35) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.552	+1.604	.003	.010	3	3
UCEC	Akt_pT308 →	+0.392	+2.115	.048	.016	3	2
UCEC	PTEN →	-0.269	-1.584	.031	.034	3	2
UCEC	Rad50 →	-0.190	-2.687	.012	.005	3	2
UCEC	beta-Catenin →	+0.365	+1.353	.022	.015	3	2
UCEC	4E-BP1_pT37_T46 →	-0.336	-1.893	.004	.014	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Caspase-7-cleavedD198 by USP35 expression — UCEC

Explore this box plot interactively →