USP35

Across TCGA cell cohorts, USP35 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,219 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible USP35-associated GO terms across cancer lineages are Positive regulation of autophagy, Cytosolic transport, and Regulation of intracellular transport. Each is linked with USP35 in more than 13 cancer types. Because this analysis shows association rather than direction, both USP35-to-partner and partner-to-USP35 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of autophagy grouped by USP35-low versus USP35-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (USP35→partner) and Y-score (partner→USP35) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Positive regulation of autophagy →	+0.043	+0.909	.008	.004	3	14
OESOPHAGUS	Cytosolic transport →	+0.074	+1.174	<.001	.006	3	14
UPPER_AERODIGESTIVE_TRACT	Regulation of intracellular transport →	+0.069	+1.652	<.001	<.001	3	14
STOMACH	Regulation of macroautophagy →	+0.078	+0.786	<.001	.001	3	14
UPPER_AERODIGESTIVE_TRACT	Endosomal transport →	+0.054	+0.912	<.001	<.001	3	14
OESOPHAGUS	Positive regulation of microtubule nucleation →	+0.135	+1.015	.002	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,219 associations by consensus.

Positive regulation of autophagy by USP35 expression — OESOPHAGUS

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