USP35

Across TCGA cell cohorts, USP35 mutation is significantly associated with the RNA expression of many other genes, with 1,549 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible USP35-associated genes across cancer lineages are MSH4, CCDC134, and CBY1. Each is linked with USP35 in more than 2 cancer types. Because this analysis shows association rather than direction, both USP35-to-partner and partner-to-USP35 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH4 grouped by USP35-low versus USP35-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP35→partner) and Y-score (partner→USP35) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MSH4 →	+0.289	+2.242	<.001	<.001	3	3
LARGE_INTESTINE	CCDC134 →	+0.750	+3.459	<.001	<.001	3	2
LARGE_INTESTINE	CBY1 →	+0.601	+3.619	<.001	<.001	3	2
LARGE_INTESTINE	JOSD1 →	+0.551	+3.584	<.001	<.001	3	2
LARGE_INTESTINE	THOC5 →	+0.497	+2.043	.006	.001	3	2
LARGE_INTESTINE	RPL3 →	+0.556	+2.874	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,549 associations by consensus.

MSH4 by USP35 expression — LARGE_INTESTINE

Explore this box plot interactively →