USP28

Across TCGA patient cohorts, USP28 protein abundance is significantly associated with the RNA expression of many other genes, with 9,735 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible USP28-associated genes across cancer lineages are RAD51AP1, CHEK1, and NCAPG. Each is linked with USP28 in more than 5 cancer types. Because this analysis shows association rather than direction, both USP28-to-partner and partner-to-USP28 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, USP28 versus RAD51AP1 in LUAD, with a Pearson correlation of 0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP28→partner) and Y-score (partner→USP28) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RAD51AP1 →	+1.018	+0.384	<.001	<.001	3	6
GBM	CHEK1 →	+1.152	+0.431	<.001	<.001	3	6
LUAD	NCAPG →	+0.921	+0.326	<.001	<.001	3	5
LUAD	FOXM1 →	+1.189	+0.341	<.001	<.001	3	5
OV	TTK →	+1.035	+0.394	<.001	.005	2	6
OV	PDGFRB →	-1.150	-0.309	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,735 associations by consensus.

USP28 vs RAD51AP1 — LUAD

Explore this scatter interactively →