USP28

Across TCGA patient cohorts, USP28 mutation is significantly associated with the RNA expression of many other genes, with 4,267 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USP28-associated genes across cancer lineages are C1QBP, CARS1, and HSPA4. Each is linked with USP28 in more than 4 cancer types. Because this analysis shows association rather than direction, both USP28-to-partner and partner-to-USP28 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1QBP grouped by USP28-low versus USP28-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP28→partner) and Y-score (partner→USP28) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C1QBP →	+0.541	+1.830	<.001	<.001	3	5
SKCM	CARS1 →	+0.410	+3.725	.002	<.001	3	5
UCEC	HSPA4 →	+0.450	+2.343	<.001	<.001	3	5
UCEC	CDCA2 →	+0.887	+2.544	<.001	<.001	3	4
UCEC	C4orf46 →	+0.589	+1.879	<.001	.004	3	4
UCEC	DNAJC9 →	+0.462	+1.946	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,267 associations by consensus.

C1QBP by USP28 expression — UCEC

Explore this box plot interactively →