USP28

Across TCGA cell cohorts, USP28 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,897 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible USP28-associated GO terms across cancer lineages are DNA damage checkpoint signaling, Sister chromatid segregation, and DNA strand elongation. Each is linked with USP28 in more than 14 cancer types. Because this analysis shows association rather than direction, both USP28-to-partner and partner-to-USP28 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA damage checkpoint signaling grouped by USP28-low versus USP28-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (USP28→partner) and Y-score (partner→USP28) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	DNA damage checkpoint signaling →	+0.097	+1.225	<.001	<.001	3	15
SOFT_TISSUE	Sister chromatid segregation →	+0.146	+1.191	<.001	<.001	3	15
PANCREAS	DNA strand elongation →	+0.146	+1.270	<.001	<.001	3	15
BLOOD_Lymphoma	Regulation of chromosome organization →	+0.074	+1.167	<.001	<.001	3	15
SOFT_TISSUE	Meiotic sister chromatid cohesion, centromeric →	+0.159	+0.994	<.001	.001	3	15
PANCREAS	Regulation of chromosome segregation →	+0.104	+1.129	<.001	.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,897 associations by consensus.

DNA damage checkpoint signaling by USP28 expression — SOFT_TISSUE

Explore this box plot interactively →