USP27X-AS1

Across TCGA pan-cancer cohorts, USP27X-AS1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated USP27X-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher USP27X-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated USP27X-AS1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and ACC show a favorable association.

KIRC, LIHC, and ACC are the cancer types where USP27X-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.708	0.546	<.001	149	view →
LIHC	OS	Tertile	All	0.675	0.839	<.001	69	view →
ACC	OS	Median	III,IV	0.829	0.176	<.001	57	view →
MESO	OS	Tertile	All	0.473	0.278	.012	45	view →
LUSC	DFS	Quartile	III,IV	0.189	0.596	.001	31	view →
SKCM	DFS	Quartile	All	0.709	0.560	.001	29	view →
LAML	DFS	Median	All	0.192	0.566	.001	26	view →
COAD	DFS	Quartile	All	0.559	0.752	.006	23	view →
ESCA	DFS	Quartile	All	0.337	0.598	.002	19	view →
KIRP	DFS	Tertile	IV	0.035	0.623	.010	12	view →
HNSC	DFS	Quartile	IV	0.702	0.540	.025	6	view →
BRCA	DFS	Quartile	III,IV	0.952	0.843	.029	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

USP27X-AS1–KIRC (DFS)

Open the KIRC breakdown →