USP27X-AS1

Across TCGA pan-cancer cohorts, USP27X-AS1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of USP27X-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where USP27X-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types USP27X-AS1 is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

THCA, LUAD, and UCEC are the cancer types where USP27X-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in USP27X-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.450	<.001	11	view →
LUAD	All	II,III,IV	−0.395	<.001	8	view →
UCEC	All	II,III,IV	−1.202	<.001	6	view →
LIHC	All	II,III,IV	+0.534	<.001	6	view →
LUSC	All	II,III,IV	−0.391	.003	5	view →
COAD	Male	All	+0.413	.013	4	view →
CHOL	All	All	+0.873	<.001	3	view →
BLCA	Female	III,IV	+0.698	.035	3	view →
KIRP	Male	All	−0.452	.001	2	view →
PRAD	All	All	−0.241	.005	2	view →
BLCA	Male	IV	−0.952	.006	1	view →
KICH	All	All	−0.367	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

USP27X-AS1–THCA

Open the THCA breakdown →