USP22

Across TCGA patient cohorts, USP22 mutation is significantly associated with the RNA expression of many other genes, with 2,935 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USP22-associated genes across cancer lineages are RNU6-886P, RNU6-1228P, and MIR610. Each is linked with USP22 in more than 1 cancer types. Because this analysis shows association rather than direction, both USP22-to-partner and partner-to-USP22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-886P grouped by USP22-low versus USP22-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP22→partner) and Y-score (partner→USP22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNU6-886P →	+0.553	+4.320	<.001	.007	3	2
BLCA	RNU6-1228P →	+0.479	+6.444	<.001	.001	3	2
COAD	MIR610 →	+0.232	+4.547	.006	.005	3	2
COAD	BPY2DP →	+0.194	+5.409	<.001	.001	3	2
LIHC	RN7SL577P →	+0.200	+5.413	<.001	<.001	3	2
SKCM	MIR6075 →	+0.357	+3.045	.002	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,935 associations by consensus.

RNU6-886P by USP22 expression — CESC

Explore this box plot interactively →