USP21

Across TCGA patient cohorts, USP21 protein abundance is significantly associated with the RNA expression of many other genes, with 305 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible USP21-associated genes across cancer lineages are RIN3, ST8SIA5, and NALCN. Each is linked with USP21 in more than 1 cancer types. Because this analysis shows association rather than direction, both USP21-to-partner and partner-to-USP21 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, USP21 versus RIN3 in HNSC, with a Pearson correlation of 0.69.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP21→partner) and Y-score (partner→USP21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RIN3 →	+0.671	+0.902	.001	.001	3	1
HNSC	ST8SIA5 →	+0.370	+0.932	<.001	<.001	3	1
HNSC	NALCN →	+1.040	+1.437	.001	.004	3	1
HNSC	FGF14 →	+1.220	+1.134	.007	.009	3	1
HNSC	PTPRZ1 →	-2.389	-1.129	.006	.004	3	1
HNSC	KCNT1 →	+0.456	+1.097	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 305 associations by consensus.

USP21 vs RIN3 — HNSC

Explore this scatter interactively →