USP21

Across TCGA pan-cancer cohorts, USP21 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated USP21 data layer compared with 5 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher USP21 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated USP21 expression acts as an unfavorable survival marker, although some lineages such as HNSC and GBM show a favorable association.

KIRC, ACC, and LIHC are the cancer types where USP21 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Quartile	II,III,IV	0.368	0.661	<.001	90	view →
ACC	DFS	Median	All	0.184	0.690	<.001	89	view →
LIHC	OS	Median	All	0.603	0.769	<.001	78	view →
KICH	OS	Median	All	0.653	1.000	.001	68	view →
COAD	DFS	Quartile	All	0.521	0.778	<.001	49	view →
KIRP	DFS	Median	IV	0.034	0.527	<.001	36	view →
HNSC	DFS	Tertile	IV	0.739	0.562	.004	33	view →
GBM	DFS	Quartile	All	0.328	0.151	<.001	32	view →
LGG	OS	Tertile	All	0.322	0.579	.005	18	view →
ESCA	DFS	Tertile	All	1.000	0.380	.005	18	view →
UCEC	DFS	Tertile	All	0.562	0.691	.013	12	view →
MESO	DFS	Median	IV	0.192	0.437	.024	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

USP21–KIRC (DFS)

Open the KIRC breakdown →