USP14

Across TCGA patient cohorts, USP14 mutation is significantly associated with the RNA expression of many other genes, with 2,105 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USP14-associated genes across cancer lineages are MIR615, RN7SKP221, and HNRNPH3P1. Each is linked with USP14 in more than 2 cancer types. Because this analysis shows association rather than direction, both USP14-to-partner and partner-to-USP14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR615 grouped by USP14-low versus USP14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP14→partner) and Y-score (partner→USP14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR615 →	+0.180	+1.910	.002	.008	3	3
BRCA	RN7SKP221 →	+0.065	+7.471	<.001	.008	3	2
BRCA	HNRNPH3P1 →	+0.080	+6.505	<.001	.001	3	2
LGG	USP9YP10 →	+0.049	+7.977	<.001	.007	3	2
BRCA	MIR3648-2 →	+0.099	+8.057	<.001	.005	3	2
UCEC	LINC01848 →	+0.065	+1.910	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,105 associations by consensus.

MIR615 by USP14 expression — UCEC

Explore this box plot interactively →