USP14

Across TCGA pan-cancer cohorts, USP14 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of USP14’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where USP14 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types USP14 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, LIHC, and LUSC are the cancer types where USP14 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in USP14 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.903	<.001	12	view →
LIHC	Male	II,III,IV	+1.232	<.001	9	view →
LUSC	All	III,IV	+0.991	<.001	8	view →
STAD	Male	II,III,IV	+0.982	<.001	8	view →
BRCA	All	All	+0.733	<.001	8	view →
LUAD	Male	II,III,IV	+0.723	<.001	8	view →
BLCA	Female	III,IV	+0.588	.001	6	view →
COAD	All	II,III,IV	+0.464	.002	6	view →
CHOL	All	All	+1.952	<.001	5	view →
KIRP	Female	II,III,IV	+0.697	.006	5	view →
THCA	All	All	−0.232	.005	5	view →
READ	All	III,IV	+0.820	.021	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

USP14–HNSC

Open the HNSC breakdown →