USP12-AS1

Across TCGA pan-cancer cohorts, USP12-AS1 RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated USP12-AS1 data layer.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher USP12-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated USP12-AS1 expression acts as an unfavorable survival marker, although some lineages such as LIHC and MESO show a favorable association.

LIHC, UCS, and MESO are the cancer types where USP12-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Tertile	All	0.941	0.672	.011	48	view →
UCS	DFS	Tertile	IV	0.132	0.718	.002	36	view →
MESO	OS	Quartile	III,IV	0.807	0.212	.019	27	view →
STAD	OS	Tertile	IV	0.712	0.206	<.001	22	view →
DLBC	DFS	Tertile	III,IV	0.070	0.855	.008	18	view →
PAAD	DFS	Tertile	III,IV	0.152	0.821	.045	9	view →
CHOL	DFS	Tertile	All	1.000	0.341	.028	9	view →
SARC	DFS	Tertile	All	0.430	0.648	.031	6	view →
UCEC	OS	Tertile	All	0.896	0.929	.042	6	view →
OV	OS	Median	IV	0.649	0.830	.037	4	view →
KIRP	OS	Tertile	All	1.000	0.921	.036	3	view →
ESCA	DFS	Median	All	0.307	0.400	.049	2	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

USP12-AS1–LIHC (OS)

Open the LIHC breakdown →