USP12-AS1

Across TCGA pan-cancer cohorts, USP12-AS1 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of USP12-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where USP12-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types USP12-AS1 is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.

LUSC, HNSC, and BRCA are the cancer types where USP12-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in USP12-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Female	All	+0.425	<.001	3	view →
HNSC	All	All	+0.164	.028	2	view →
BRCA	All	III,IV	−0.104	.019	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

USP12-AS1–LUSC

Open the LUSC breakdown →