Q-omics provides the consensus-scored USP12-AS1 profile across patient tissues and cancer cell-line models. USP12-AS1 expression is associated with patient survival in 13 of 34 cancer types, with the highest sampling consensus in LIHC. Among the 18 cancer types available for tumor–normal comparison, USP12-AS1 is differentially expressed in 3, with the highest sampling consensus in LUSC. Additionally, USP12-AS1 RNA expression shows 6,471 significant protein co-abundance associations, with the highest sampling consensus in LUAD. Together, these results highlight LIHC, LUSC, and LUAD as cancer lineages where USP12-AS1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for USP12-AS1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes USP12-AS1 survival associations across molecular data types. USP12-AS1 RNA expression shows survival associations in the most cancer types (13). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible USP12-AS1 RNA expression–survival associations across cancer types. High USP12-AS1 expression shows unfavorable associations in UCS and DLBC, but favorable associations in LIHC, MESO, STAD and CHOL. The LIHC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p = .011). Together, the overview and detailed table identify LIHC as the clearest survival context for USP12-AS1 RNA expression.
This table summarizes USP12-AS1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 3. The strongest signals are observed in LUSC for RNA.
This table ranks reproducible tumor–normal expression differences for USP12-AS1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. USP12-AS1 shows lower tumor expression in BRCA and higher tumor expression in LUSC and HNSC. The LUSC box plot shows higher USP12-AS1 RNA expression in tumor versus normal tissue (log2 FC = +0.425, t-test p < 0.001).
This table shows molecular features associated with USP12-AS1 in patient tissues and cancer cell lines. In patient samples, USP12-AS1 shows the broadest associations at the RNA and protein expression levels, with LUAD recurring as the lineage with the largest associated feature set.
