URGCP-MRPS24

Across TCGA patient cohorts, URGCP-MRPS24 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible URGCP-MRPS24-associated genes across cancer lineages are RNU4-58P, RNA5SP51, and RNU6-806P. Each is linked with URGCP-MRPS24 in more than 1 cancer types. Because this analysis shows association rather than direction, both URGCP-MRPS24-to-partner and partner-to-URGCP-MRPS24 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU4-58P grouped by URGCP-MRPS24-low versus URGCP-MRPS24-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (URGCP-MRPS24→partner) and Y-score (partner→URGCP-MRPS24) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU4-58P →	+0.497	+5.133	.001	.008	3	1
UCEC	RNA5SP51 →	+1.306	+6.582	<.001	.001	3	1
UCEC	RNU6-806P →	+0.869	+6.335	<.001	.001	3	1
UCEC	RNU6-152P →	+0.713	+5.621	<.001	.004	3	1
UCEC	RNU6-364P →	+0.848	+5.771	<.001	.003	3	1
UCEC	MIR1302-7 →	+1.041	+6.123	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

RNU4-58P by URGCP-MRPS24 expression — UCEC

Explore this box plot interactively →