UQCRQ

Across TCGA patient cohorts, UQCRQ mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UQCRQ-associated genes across cancer lineages are GOLGA6C, OR5B2, and OR2T1. Each is linked with UQCRQ in more than 1 cancer types. Because this analysis shows association rather than direction, both UQCRQ-to-partner and partner-to-UQCRQ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GOLGA6C grouped by UQCRQ-low versus UQCRQ-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UQCRQ→partner) and Y-score (partner→UQCRQ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GOLGA6C →	+0.114	+5.302	<.001	.001	3	1
UCEC	OR5B2 →	+0.101	+4.551	.001	.009	3	1
UCEC	OR2T1 →	+0.098	+4.937	<.001	.005	3	1
UCEC	MIR4518 →	+0.769	+4.398	.008	.006	3	1
UCEC	BNIP3P13 →	+0.248	+4.840	.002	.003	3	1
UCEC	MIR7845 →	+1.226	+4.423	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

GOLGA6C by UQCRQ expression — UCEC

Explore this box plot interactively →