UQCRQ

Across TCGA pan-cancer cohorts, UQCRQ RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated UQCRQ data layer compared with 6 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher UQCRQ RNA is associated with worse overall survival. In most high-consensus cancer types, elevated UQCRQ expression acts as an unfavorable survival marker, although some lineages such as KIRC and BLCA show a favorable association.

UVM, LUAD, and UCS are the cancer types where UQCRQ RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.382	0.885	<.001	148	view →
LUAD	OS	Quartile	III,IV	0.325	0.756	<.001	92	view →
UCS	OS	Tertile	II,III,IV	0.355	0.870	<.001	88	view →
KICH	OS	Median	II,III,IV	0.644	1.000	.001	82	view →
SKCM	DFS	Quartile	II,III,IV	0.534	0.864	<.001	52	view →
LGG	DFS	Median	All	0.643	0.829	<.001	51	view →
SCLC	DFS	Quartile	All	0.219	0.658	<.001	31	view →
CHOL	DFS	Median	All	0.128	0.661	.002	27	view →
ACC	OS	Tertile	III,IV	0.352	0.729	.014	17	view →
READ	OS	Tertile	IV	0.491	0.933	.006	16	view →
KIRC	DFS	Tertile	II,III,IV	0.697	0.428	.005	14	view →
ESCA	OS	Tertile	IV	0.247	0.922	.024	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

UQCRQ–UVM (OS)

Open the UVM breakdown →