UQCRHL

Across TCGA patient cohorts, UQCRHL mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UQCRHL-associated genes across cancer lineages are EGFR_pY1068, JNK_pT183_Y185, and MEK1. Each is linked with UQCRHL in more than 1 cancer types. Because this analysis shows association rather than direction, both UQCRHL-to-partner and partner-to-UQCRHL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by UQCRHL-low versus UQCRHL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UQCRHL→partner) and Y-score (partner→UQCRHL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.298	-3.321	.023	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.185	-3.000	.036	.036	3	1
UCEC	MEK1 →	+0.485	+3.321	.011	.010	3	1
UCEC	MIG-6 →	+0.112	+2.183	.031	.035	3	1
UCEC	PKC-b-II_pS660 →	-0.467	-3.321	.001	.010	3	1
UCEC	STAT3_pY705 →	-0.680	-3.321	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

EGFR_pY1068 by UQCRHL expression — UCEC

Explore this box plot interactively →