UPK1B

Across TCGA patient cohorts, UPK1B mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UPK1B-associated genes across cancer lineages are 14-3-3_beta, Fibronectin, and Annexin-1. Each is linked with UPK1B in more than 1 cancer types. Because this analysis shows association rather than direction, both UPK1B-to-partner and partner-to-UPK1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by UPK1B-low versus UPK1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UPK1B→partner) and Y-score (partner→UPK1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.130	-2.308	.010	.036	3	2
UCEC	Fibronectin →	-0.414	-2.986	.012	.035	3	1
UCEC	Annexin-1 →	+0.989	+3.169	<.001	.018	3	1
UCEC	ATM →	-0.507	-2.321	.025	.035	3	1
UCEC	CD31 →	-0.167	-2.321	.024	.035	3	1
UCEC	eIF4G →	+0.309	+2.321	.047	.035	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

14-3-3_beta by UPK1B expression — UCEC

Explore this box plot interactively →