UPK1B

Across TCGA pan-cancer cohorts, UPK1B RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated UPK1B data layer compared with 3 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher UPK1B RNA is associated with worse overall survival. In most high-consensus cancer types, elevated UPK1B expression acts as an unfavorable survival marker, although some lineages such as KIRP and UCEC show a favorable association.

STAD, KIRP, and UCEC are the cancer types where UPK1B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Median	All	0.310	0.524	<.001	103	view →
KIRP	DFS	Tertile	II,III,IV	0.768	0.197	<.001	90	view →
UCEC	OS	Tertile	All	0.941	0.838	<.001	50	view →
LUAD	DFS	Median	All	0.279	0.398	.001	35	view →
LGG	DFS	Median	All	0.308	0.470	<.001	35	view →
OV	OS	Quartile	IV	0.532	0.215	.009	32	view →
BRCA	OS	Tertile	III,IV	0.851	0.951	.004	32	view →
UVM	OS	Tertile	III,IV	0.214	0.768	.005	28	view →
CHOL	OS	Tertile	II,III,IV	0.437	1.000	.007	28	view →
KICH	OS	Median	II,III,IV	0.849	0.988	.003	21	view →
MESO	OS	Median	All	0.628	0.452	.018	17	view →
SKCM	OS	Quartile	All	0.693	0.812	.001	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

UPK1B–STAD (OS)

Open the STAD breakdown →