UPK1B

Across TCGA pan-cancer cohorts, UPK1B RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of UPK1B’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where UPK1B RNA is repressed in tumor relative to normal tissue. In most cancer types UPK1B is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and LUSC are the cancer types where UPK1B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UPK1B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	−2.041	<.001	12	view →
KICH	Female	All	−3.612	<.001	11	view →
LUSC	All	II,III,IV	+3.525	<.001	6	view →
LIHC	All	All	−0.176	<.001	4	view →
BLCA	All	All	+2.500	.032	2	view →
UCEC	All	All	+1.352	.044	2	view →
PRAD	All	All	−0.358	.024	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

UPK1B–KIRC

Open the KIRC breakdown →