UPF2

Across TCGA patient cohorts, UPF2 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UPF2-associated genes across cancer lineages are ASNS, eIF4G, and TFRC. Each is linked with UPF2 in more than 2 cancer types. Because this analysis shows association rather than direction, both UPF2-to-partner and partner-to-UPF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by UPF2-low versus UPF2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UPF2→partner) and Y-score (partner→UPF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.433	+1.392	<.001	.017	3	3
UCEC	eIF4G →	+0.212	+2.222	.027	.009	3	2
UCEC	TFRC →	+0.637	+3.087	<.001	<.001	3	2
UCEC	ATM →	-0.317	-2.209	.024	.009	3	2
UCEC	BRCA2 →	-0.100	-1.989	.013	.008	3	2
UCEC	C-Raf →	+0.133	+1.415	.002	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

ASNS by UPF2 expression — UCEC

Explore this box plot interactively →