UPF2

Across TCGA pan-cancer cohorts, UPF2 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of UPF2’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where UPF2 RNA is repressed in tumor relative to normal tissue. In most cancer types UPF2 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, HNSC, and LIHC are the cancer types where UPF2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UPF2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−0.765	<.001	10	view →
HNSC	All	II,III,IV	+0.492	<.001	10	view →
LIHC	All	II,III,IV	+0.814	<.001	8	view →
STAD	All	II,III,IV	+0.782	<.001	7	view →
KICH	Female	All	−1.424	<.001	5	view →
BLCA	Female	III,IV	+0.657	.005	5	view →
LUSC	All	II,III,IV	+0.545	<.001	5	view →
CHOL	Male	All	+1.856	<.001	3	view →
KIRC	All	All	+0.252	.006	3	view →
ESCA	Female	All	+0.859	.029	2	view →
LUAD	Male	All	+0.337	.045	1	view →
KIRP	Male	All	−0.336	.027	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

UPF2–THCA

Open the THCA breakdown →