UNC79

Across TCGA cell cohorts, UNC79 mutation is significantly associated with the RNA expression of many other genes, with 740 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UNC79-associated genes across cancer lineages are RNF125, LYG1, and FAM102B. Each is linked with UNC79 in more than 2 cancer types. Because this analysis shows association rather than direction, both UNC79-to-partner and partner-to-UNC79 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNF125 grouped by UNC79-low versus UNC79-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UNC79→partner) and Y-score (partner→UNC79) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RNF125 →	+0.857	+2.458	<.001	<.001	3	3
LARGE_INTESTINE	LYG1 →	+0.787	+2.458	<.001	<.001	3	3
LARGE_INTESTINE	FAM102B →	+0.773	+3.584	.002	<.001	3	3
LARGE_INTESTINE	CHCHD4 →	+0.422	+2.652	.006	.001	3	3
LARGE_INTESTINE	IMPDH2 →	+0.423	+2.584	.003	.002	3	3
LARGE_INTESTINE	FAM86B1 →	+1.090	+2.807	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 740 associations by consensus.

RNF125 by UNC79 expression — LARGE_INTESTINE

Explore this box plot interactively →