UNC5C

Across TCGA patient cohorts, UNC5C mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UNC5C-associated genes across cancer lineages are Bcl-2, LKB1, and Stathmin. Each is linked with UNC5C in more than 2 cancer types. Because this analysis shows association rather than direction, both UNC5C-to-partner and partner-to-UNC5C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Bcl-2 grouped by UNC5C-low versus UNC5C-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UNC5C→partner) and Y-score (partner→UNC5C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Bcl-2 →	-0.387	-1.874	.004	.047	3	3
COAD	LKB1 →	+0.086	+2.230	.021	.006	3	2
COAD	Stathmin →	+0.153	+2.334	.008	.018	3	2
COAD	Caspase-7-cleavedD198 →	+1.197	+3.338	<.001	.004	3	2
COAD	cIAP →	+0.135	+3.334	.005	.005	2	3
COAD	C-Raf →	+0.147	+2.356	.008	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

Bcl-2 by UNC5C expression — SKCM

Explore this box plot interactively →