UNC5C

Across TCGA pan-cancer cohorts, UNC5C RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of UNC5C’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where UNC5C RNA is repressed in tumor relative to normal tissue. In most cancer types UNC5C is over-expressed in tumor, although a few such as COAD and BLCA show the opposite, repressed pattern.

COAD, BLCA, and KIRP are the cancer types where UNC5C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UNC5C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−1.904	<.001	12	view →
BLCA	All	All	−1.143	<.001	11	view →
KIRP	Female	All	−1.186	<.001	9	view →
KICH	All	All	−0.766	<.001	6	view →
READ	All	All	−1.310	<.001	5	view →
LUSC	All	II,III,IV	−0.825	<.001	5	view →
BRCA	Female	All	−0.412	<.001	4	view →
THCA	Male	All	−0.591	.005	3	view →
UCEC	All	All	−0.775	.030	2	view →
PRAD	All	All	−0.301	.047	2	view →
CHOL	All	All	+0.556	.008	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

UNC5C–COAD

Open the COAD breakdown →