UNC5C

Across TCGA pan-cancer cohorts, UNC5C RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated UNC5C data layer compared with 8 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher UNC5C RNA is associated with worse overall survival. In most high-consensus cancer types, elevated UNC5C expression acts as an unfavorable survival marker, although some lineages such as KIRC and LIHC show a favorable association.

BLCA, KIRP, and UVM are the cancer types where UNC5C RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	All	0.646	0.771	<.001	124	view →
KIRP	OS	Quartile	All	0.823	0.963	<.001	120	view →
UVM	DFS	Tertile	II,III,IV	0.299	0.644	.003	60	view →
KIRC	DFS	Tertile	All	0.867	0.764	.001	58	view →
OV	OS	Median	II,III,IV	0.647	0.735	.006	42	view →
LGG	OS	Median	All	0.747	0.867	<.001	41	view →
STAD	DFS	Median	All	0.479	0.622	.005	27	view →
CESC	OS	Quartile	III,IV	0.612	0.914	.006	20	view →
LIHC	DFS	Median	III,IV	0.570	0.237	.002	15	view →
MESO	OS	Quartile	All	0.287	0.540	.010	12	view →
LUAD	OS	Tertile	II,III,IV	0.858	0.691	.012	12	view →
LUSC	DFS	Quartile	II,III,IV	0.485	0.734	.005	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

UNC5C–BLCA (OS)

Open the BLCA breakdown →