UNC5C

Across TCGA cell cohorts, UNC5C mutation is significantly associated with the RNA expression of many other genes, with 44 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UNC5C-associated genes across cancer lineages are FCN1, CD300H, and OR6C2. Each is linked with UNC5C in more than 1 cancer types. Because this analysis shows association rather than direction, both UNC5C-to-partner and partner-to-UNC5C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FCN1 grouped by UNC5C-low versus UNC5C-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UNC5C→partner) and Y-score (partner→UNC5C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	FCN1 →	+0.481	+3.514	.001	.008	3	2
BREAST	CD300H →	+0.220	+4.199	<.001	.007	3	2
BLOOD_Myeloma	OR6C2 →	+0.034	+3.906	<.001	.009	3	1
BLOOD_Myeloma	ETV3L →	+0.012	+4.285	<.001	.003	3	1
LUNG_NSCLC_LUSC	LCE1A →	+0.126	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	CFAP97D2 →	+0.020	+4.643	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

FCN1 by UNC5C expression — BLOOD_Lymphoma

Explore this box plot interactively →