UNC45A

Across TCGA patient cohorts, UNC45A mutation is significantly associated with the RNA expression of many other genes, with 3,211 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UNC45A-associated genes across cancer lineages are RNU6-1067P, GINS3, and NDC80. Each is linked with UNC45A in more than 2 cancer types. Because this analysis shows association rather than direction, both UNC45A-to-partner and partner-to-UNC45A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1067P grouped by UNC45A-low versus UNC45A-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UNC45A→partner) and Y-score (partner→UNC45A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-1067P →	+0.317	+2.652	<.001	.004	3	3
UCEC	GINS3 →	+0.541	+2.191	<.001	<.001	3	3
UCEC	NDC80 →	+0.541	+1.914	.007	<.001	3	3
UCEC	SEH1L →	+0.367	+2.425	.002	.001	3	3
COAD	HSPE1P10 →	+0.223	+2.761	<.001	.008	3	3
UCEC	CEP76 →	+0.380	+2.436	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,211 associations by consensus.

RNU6-1067P by UNC45A expression — SKCM

Explore this box plot interactively →