UNC45A

Across TCGA pan-cancer cohorts, UNC45A RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated UNC45A data layer compared with 1 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher UNC45A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated UNC45A expression acts as an unfavorable survival marker, although some lineages such as SCLC and KIRC show a favorable association.

KICH, SKCM, and SCLC are the cancer types where UNC45A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Quartile	III,IV	0.059	1.000	.001	102	view →
SKCM	OS	Tertile	All	0.251	0.404	<.001	77	view →
SCLC	DFS	Quartile	All	0.720	0.311	<.001	61	view →
LIHC	DFS	Quartile	All	0.312	0.494	<.001	60	view →
LGG	DFS	Median	All	0.267	0.552	<.001	54	view →
KIRC	OS	Median	All	0.721	0.530	<.001	47	view →
HNSC	OS	Quartile	All	0.159	0.652	.002	34	view →
UCEC	DFS	Quartile	II,III,IV	0.900	0.793	.010	26	view →
LAML	DFS	Tertile	All	0.397	0.682	.017	24	view →
MESO	DFS	Median	IV	0.207	0.506	.005	21	view →
DLBC	DFS	Median	III,IV	0.169	0.984	.001	20	view →
KIRP	DFS	Quartile	IV	0.031	0.683	.038	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

UNC45A–KICH (DFS)

Open the KICH breakdown →