UNC13A

Across TCGA patient cohorts, UNC13A mutation is significantly associated with the total protein of many other genes, with 75 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UNC13A-associated genes across cancer lineages are p38-MAPK_pT180_Y182, PCNA, and GAPDH. Each is linked with UNC13A in more than 4 cancer types. Because this analysis shows association rather than direction, both UNC13A-to-partner and partner-to-UNC13A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by UNC13A-low versus UNC13A-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UNC13A→partner) and Y-score (partner→UNC13A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	p38-MAPK_pT180_Y182 →	-0.474	-2.321	.002	.032	3	4
STAD	PCNA →	+0.493	+3.321	<.001	.010	2	5
UCEC	GAPDH →	+0.429	+2.222	.012	.009	3	4
COAD	Caspase-7-cleavedD198 →	+1.262	+2.593	<.001	.006	3	4
UCEC	Cyclin-E2 →	+0.151	+1.523	.005	.008	3	4
UCEC	eEF2 →	+0.327	+2.115	.004	.016	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 75 associations by consensus.

p38-MAPK_pT180_Y182 by UNC13A expression — LUAD

Explore this box plot interactively →