UNC13A

Across TCGA cell cohorts, UNC13A mutation is significantly associated with the RNA expression of many other genes, with 1,752 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UNC13A-associated genes across cancer lineages are HPF1, ACOT8, and DVL1. Each is linked with UNC13A in more than 1 cancer types. Because this analysis shows association rather than direction, both UNC13A-to-partner and partner-to-UNC13A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HPF1 grouped by UNC13A-low versus UNC13A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UNC13A→partner) and Y-score (partner→UNC13A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HPF1 →	+0.841	+3.459	<.001	<.001	3	2
LARGE_INTESTINE	ACOT8 →	-0.628	-2.072	<.001	.008	3	2
LARGE_INTESTINE	DVL1 →	+0.714	+3.949	.001	<.001	3	2
LARGE_INTESTINE	SLAIN2 →	+0.664	+2.158	<.001	.004	3	2
LARGE_INTESTINE	SEPSECS →	+0.677	+3.459	<.001	.001	3	2
LARGE_INTESTINE	CYP27B1 →	+0.902	+2.523	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,752 associations by consensus.

HPF1 by UNC13A expression — LARGE_INTESTINE

Explore this box plot interactively →