UMODL1

Across TCGA cell cohorts, UMODL1 mutation is significantly associated with the RNA expression of many other genes, with 537 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UMODL1-associated genes across cancer lineages are GPR33, SIGLEC12, and DUX4. Each is linked with UMODL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both UMODL1-to-partner and partner-to-UMODL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR33 grouped by UMODL1-low versus UMODL1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UMODL1→partner) and Y-score (partner→UMODL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GPR33 →	+0.010	+3.189	.002	.007	3	3
LUNG_SCLC	SIGLEC12 →	+0.032	+3.459	<.001	.003	3	2
LARGE_INTESTINE	DUX4 →	+0.032	+3.584	.004	.003	3	2
STOMACH	MAGEB5 →	+0.050	+3.432	<.001	.008	3	2
BLOOD_Leukemia	DLG5 →	+1.022	+3.199	.008	.007	2	3
BLOOD_Leukemia	DHRS11 →	+1.060	+3.199	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 537 associations by consensus.

GPR33 by UMODL1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →