UMODL1

Across TCGA pan-cancer cohorts, UMODL1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of UMODL1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where UMODL1 RNA is repressed in tumor relative to normal tissue. In most cancer types UMODL1 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, LUAD, and KIRP are the cancer types where UMODL1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UMODL1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	−0.431	<.001	12	view →
LUAD	All	All	+0.772	<.001	10	view →
KIRP	Male	All	−0.522	<.001	9	view →
BRCA	All	III,IV	+0.526	<.001	6	view →
COAD	All	All	+0.316	.001	6	view →
THCA	All	All	−0.034	<.001	6	view →
KICH	All	All	+0.603	.034	2	view →
LUSC	All	All	+0.216	.006	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

UMODL1–KIRC

Open the KIRC breakdown →