UMODL1

Across TCGA pan-cancer cohorts, UMODL1 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated UMODL1 data layer compared with 7 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher UMODL1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated UMODL1 expression acts as an unfavorable survival marker, although some lineages such as CESC and LUAD show a favorable association.

ACC, CESC, and LUAD are the cancer types where UMODL1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.459	0.767	<.001	121	view →
CESC	OS	Median	All	0.876	0.714	<.001	100	view →
LUAD	OS	Tertile	III,IV	0.770	0.467	<.001	83	view →
THCA	OS	Quartile	All	0.962	0.999	<.001	67	view →
LGG	DFS	Median	All	0.658	0.811	<.001	49	view →
KIRC	DFS	Median	All	0.759	0.838	.004	47	view →
STAD	DFS	Median	III,IV	0.205	0.461	.002	46	view →
LUSC	OS	Tertile	All	0.820	0.724	.003	31	view →
BRCA	OS	Tertile	III,IV	0.426	0.702	.004	29	view →
MESO	OS	Tertile	All	0.203	0.644	<.001	27	view →
UVM	OS	Median	III,IV	0.246	0.836	.003	21	view →
THYM	OS	Tertile	All	0.941	0.696	.009	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

UMODL1–ACC (DFS)

Open the ACC breakdown →