UMOD

Across TCGA patient cohorts, UMOD mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UMOD-associated genes across cancer lineages are Cyclin-B1, TIGAR, and Caspase-7-cleavedD198. Each is linked with UMOD in more than 2 cancer types. Because this analysis shows association rather than direction, both UMOD-to-partner and partner-to-UMOD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by UMOD-low versus UMOD-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UMOD→partner) and Y-score (partner→UMOD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	Cyclin-B1 →	+0.907	+3.000	<.001	.035	3	3
LUSC	TIGAR →	+0.161	+2.215	.014	.032	3	3
UCEC	Caspase-7-cleavedD198 →	+0.511	+1.125	.004	.033	3	3
UCEC	c-Met_pY1235 →	+0.058	+1.450	.010	.014	3	3
LUAD	FoxM1 →	+0.479	+3.321	<.001	.010	3	2
LUAD	Cyclin-E2 →	+0.168	+2.186	.011	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

Cyclin-B1 by UMOD expression — LUAD

Explore this box plot interactively →