UMOD

Across TCGA pan-cancer cohorts, UMOD RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of UMOD’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where UMOD RNA is repressed in tumor relative to normal tissue. In most cancer types UMOD is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and KIRP are the cancer types where UMOD tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UMOD RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	IV	−11.465	<.001	12	view →
KICH	Male	IV	−13.233	<.001	11	view →
KIRP	Female	II,III,IV	−11.905	<.001	11	view →
BRCA	All	All	+0.183	.003	4	view →
COAD	All	All	−0.006	.009	4	view →
ESCA	All	All	−0.282	.012	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

UMOD–KIRC

Open the KIRC breakdown →