UMOD

Across TCGA pan-cancer cohorts, UMOD RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated UMOD data layer compared with 10 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher UMOD RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated UMOD expression acts as an unfavorable survival marker, although some lineages such as BRCA and CHOL show a favorable association.

ACC, COAD, and LUSC are the cancer types where UMOD RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Tertile	III,IV	0.047	0.380	<.001	45	view →
COAD	OS	Tertile	IV	0.101	0.658	<.001	36	view →
LUSC	OS	Tertile	III,IV	0.182	0.794	.002	36	view →
LGG	DFS	Tertile	All	0.681	0.866	.001	24	view →
MESO	DFS	Tertile	All	0.176	0.530	.031	18	view →
LIHC	OS	Tertile	II,III,IV	0.504	0.653	.008	17	view →
BRCA	OS	Tertile	All	0.947	0.907	.010	11	view →
BLCA	OS	Tertile	IV	0.394	0.605	.026	9	view →
CHOL	DFS	Tertile	II,III,IV	0.776	0.199	.044	6	view →
KIRP	DFS	Quartile	IV	0.537	0.888	.038	6	view →
PAAD	OS	Quartile	All	0.255	0.564	.018	6	view →
STAD	OS	Tertile	II,III,IV	0.476	0.615	.034	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

UMOD–ACC (DFS)

Open the ACC breakdown →