UMOD

Across TCGA cell cohorts, UMOD RNA expression is significantly associated with the go_rna of many other GO terms, with 76 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible UMOD-associated GO terms across cancer lineages are Positive regulation of mitophagy, Regulation of mitophagy, and Regulation of autophagy of mitochondrion. Each is linked with UMOD in more than 1 cancer types. Because this analysis shows association rather than direction, both UMOD-to-partner and partner-to-UMOD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of mitophagy grouped by UMOD-low versus UMOD-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (UMOD→partner) and Y-score (partner→UMOD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Positive regulation of mitophagy →	+0.101	+0.096	<.001	.002	3	2
LUNG_SCLC	Regulation of mitophagy →	+0.067	+0.058	.001	.005	3	2
LUNG_SCLC	Regulation of autophagy of mitochondrion →	+0.068	+0.097	.001	.006	3	2
SKIN	D-amino acid transport →	-0.750	-0.032	.007	.006	3	2
SKIN	Regulation of myotube differentiation →	+0.052	+0.032	.007	.005	3	1
SKIN	Norrin signaling pathway →	-0.877	-0.044	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 76 associations by consensus.

Positive regulation of mitophagy by UMOD expression — LUNG_SCLC

Explore this box plot interactively →