UMOD

Across TCGA cell cohorts, UMOD mutation is significantly associated with the RNA expression of many other genes, with 287 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UMOD-associated genes across cancer lineages are SCAI, SERPINA9, and CFB. Each is linked with UMOD in more than 1 cancer types. Because this analysis shows association rather than direction, both UMOD-to-partner and partner-to-UMOD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCAI grouped by UMOD-low versus UMOD-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UMOD→partner) and Y-score (partner→UMOD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SCAI →	+0.367	+3.224	.002	.005	3	2
LUNG_SCLC	SERPINA9 →	+0.032	+3.070	<.001	.009	3	2
LARGE_INTESTINE	CFB →	-1.483	-3.169	.001	.009	3	2
LUNG_NSCLC_LUAD	SLC16A8 →	+0.645	+2.621	.009	.003	3	1
LUNG_NSCLC_LUAD	CSF2RB →	+0.236	+2.954	.001	.001	3	1
LUNG_NSCLC_LUAD	GAB1 →	+0.889	+3.321	.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 287 associations by consensus.

SCAI by UMOD expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →