UGT2B27P

Across TCGA patient cohorts, UGT2B27P mutation is significantly associated with the RNA expression of many other genes, with 2,064 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UGT2B27P-associated genes across cancer lineages are ATXN3L, MIR302D, and CCL27. Each is linked with UGT2B27P in more than 1 cancer types. Because this analysis shows association rather than direction, both UGT2B27P-to-partner and partner-to-UGT2B27P results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATXN3L grouped by UGT2B27P-low versus UGT2B27P-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UGT2B27P→partner) and Y-score (partner→UGT2B27P) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ATXN3L →	+0.028	+4.754	<.001	.005	3	2
HNSC	MIR302D →	+0.680	+4.654	<.001	.001	3	2
SARC	CCL27 →	+0.058	+5.477	<.001	.004	3	2
LGG	OR52B4 →	+0.069	+5.392	<.001	.005	3	2
STAD	OR4A40P →	+0.156	+4.363	.005	.007	3	2
STAD	FAM74A6 →	+0.066	+4.184	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,064 associations by consensus.

ATXN3L by UGT2B27P expression — HNSC

Explore this box plot interactively →