UGT2B27P

Across TCGA pan-cancer cohorts, UGT2B27P RNA is linked to patient survival in 9 of 34 cancer types, making it the most broadly survival-associated UGT2B27P data layer compared with 7 for mutation status.

The strongest signal is observed in cholangiocarcinoma (CHOL), where higher UGT2B27P RNA is associated with worse overall survival. In most high-consensus cancer types, elevated UGT2B27P expression acts as an unfavorable survival marker, although some lineages such as BLCA and KIRP show a favorable association.

CHOL, BLCA, and GBM are the cancer types where UGT2B27P RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CHOL	OS	Median	II,III,IV	0.295	0.978	<.001	66	view →
BLCA	OS	Tertile	All	0.931	0.336	.005	57	view →
GBM	DFS	Tertile	All	0.043	0.243	.003	18	view →
KIRP	OS	Median	II,III,IV	0.703	0.369	.004	13	view →
THYM	DFS	Tertile	All	0.545	0.883	.029	9	view →
STAD	DFS	Tertile	IV	0.083	0.379	.001	9	view →
ACC	DFS	Tertile	II,III,IV	0.226	0.725	.009	9	view →
CESC	DFS	Tertile	All	0.950	0.810	.036	6	view →
LIHC	OS	Median	III,IV	0.732	0.471	.020	4	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

UGT2B27P–CHOL (OS)

Open the CHOL breakdown →